Approximately 170 species of cuscuta are extensively distributed in temperate and subtropical areas of the world. Ssr tamil university volume ii free ebook download as pdf file. The effects of restraint on uptake of radioactive sulfate in the salivary and gastric secretions of rats with pyloric ligation. The compound carbenoxolone synthesized from glycyrrhizin plays key role in healing mouth and gastric ulcers along with reducing gastric secretions and promoting. Plants are known to play critical roles in the discovery and developments of new pharmaceuticals. Patel department of pharmacology, institute of pharmacy, nirma university, ahmedabad, 1maliba pharmacy college, bardoli, surat, gujarat, india. Medicinal plants are the natures gift to human being to make disease free healthy life. China 2 department of biochemistry, pharmacology and toxicology, faculty of veterinary medicine, wroclaw university of environment and life science, norwida 31. Sarsasapogenin and shatavarin iiv are present in roots, leaves, and fruits of asparagus species. Its underground stems and roots are used for medicinal purpose.
Flavanones from sorghum bicolor selectively inhibit cox2. Metabolomic profiling of five agave leaf taxa via uhplc. Immunomodulatory effects of betulinic acid from the bark of white birch on mice jine yi, 1 bozena obminskamrukowicz, 2 liyun yuan, 1 and hui yuan 1 1 college of animal medicine, hunan agricultural university, changsha, 410128, p. Compendium of medicinal and aromatic plants volume 2 free ebook download as pdf file. Against indomethacin plus pyloric ligationinduced gastric ulcer in rats to. Phenolic contents of ethanolic extracts of herbs were high compared to their aqueous extracts. The antioxidant activities of vidarikand pueraria tuberosa, shatavari asparagus racemosus and ashwagandha withania somnifera extracts aqueous and ethanolic were evaluated and compared with bha using. Antiulcer activity treatment with ethanolic extract of c. Shatavari was found to relive most of the symptoms in majority of the patients. Metabolomic profiling of five agave leaf taxa via uhplcpda.
June 2014 pdf vermont center for integrative herbalism. The possible antioxidant effects asparagus racemosus against membrane damage induced by the free radicals generated during gammaradiation were examined in rat liver mitochondria. To view the information properly, your browser needs to have the required plugins or software. Asparagus racemosusethnopharmacological evaluation and. No category june 2014 pdf vermont center for integrative herbalism. Results were compared with the standard antiulcer drug omeprazole. Evaluation of acute toxicity and gastroprotective activity. Agave plants proved to possess significant anticancer, immunostimulant, antiinflammatory, antimicrobial and antioxidant properties, owing to the prevailing.
Methods we freely listed the medicinal plants used in the bsm literature, current formulations, and the medicinal plants inventory documents. More study is needed on humans before asparagus racemosus can be safely recommended as a diuretic. Methanol extracts from the leaves of intsia bijuga, cynometra ramiflora. Licorice or mulethi is a medicinal herb which is used in various ayurvedic medicines. The possible antioxidant effects asparagus racemosus against membrane damage induced by the free radicals generated during gammaradiation were examined in. Synthesis of sarsasapogenin in the callus culture of a. Effect of added herb extracts on oxidative stability of. Agaves family agavaceae are perennial plants, native to mexico and southwestern united states. Active constituents of asparagus racemosus steroidal saponins are main active constituents of a. Indian medicinal plants, peptic ulcer, ocimum sanctum. Metabolite profiling in biomarker discovery, enzyme substrate assignment, drug activityspecificity determination, and basic metabolic research requires new data preprocessing approaches to correlate specific metabolites to their biological origin. Asparagus racemosus, steroidal saponins, application, herbal. Asparagus racemosus is an ayurvedic rasayana, which finds mention in.
The anticancer activity of shatavarins containing shatavarin iv isolated from the roots of. Toxicological survey of african medicinal plants mafiadoc. The hematinic activity was conducted in swiss albino rats by single intra peritoneal injection of phenyl hydrazine at a dose of 20mgkg b. Siotone st is a herbal formulation comprising of withania somnifera, ocimum sanctum, asparagus racemosus, tribulus terristris and shilajit, all of which are classified in ayurveda as rasayanas which are reputed to promote physical and mental health, improve defence mechanisms of the body and enhance longevity. Antioxidant activity and antiapoptotic effect of asparagus racemosus root extracts in human lung epithelial h460 cells. Summary the present study was undertaken to investigate the effect of asparagus racemosus. Pharmacological evaluation for antidepressantlike activity of asparagus racemosus willd. Drug treatment was carried out for 14 days at 2 dose level 200mgkg p. For example, the pdf reader software is required to view the pdf format document. Shatavarin iv is a glycoside of sarsasapogenin having two molecules of rhamnose and one molecule of glucose.
The study found that 3,200 milligrams of asparagus racemosus had diuretic activity without causing acute side effects. Evaluation of burn wound healing activity of topical regular insulin in normal and diabetic rats bairy kl, abhinav r. The present study evaluates the effects of extract of musa sapientum fruit mse on ulcer index, blood glucose level and gastric mucosal cytokines, tnf. The aim of the present study is to investigate the gastroprotective activity of c.
In asparagus racemosus, there is an almost 100% mark up in price from the collector level to the user tewari, 2000. Evaluation of acute toxicity and gastroprotective activity of. Its medicinal properties are reported in traditional systems of medicine such as ayurveda, siddha and unani. The major bioactives chemical constituents of asparagus species are shown in figure 2. Bhatnagar m, sisodia ss, 2006, antisecretory and antiulcer activity of asparagus racemosus wild, against indomethacin plus phyloric ligationinduced ga stric ulcer in rats. All tests were performed in triplicate, expressed as mean sem and presented in tables and bar graphs where appropriate. There is urgent need to document the medicinal and aromatic plants associated traditional knowledge which is vulnerable to minimize. Acute toxicity test was carried out on 36 rats 18 males and 18 females with low dose of. Here we introduce an lcmsbased data analysis approach, xcms, which incorporates novel nonlinear retention time alignment, matched filtration. The effect of saptachchhada kwatha and pinda taila on vipadika tenia pedis treatment of duodenal ulcer with asparagus racemosus linn. The percentage atpase inhibitory activity of the extract and omeprazole was also expressed in terms of 50% inhibitory concentration ic 50 value. Gastric ulceration studies have been further carried out to study the antiulcer effect of the ethanolic extract and its various fractions at dose of 900 mgkg body weight.
Species of this genus are widely used as essential constituents in functional foods and traditional medicinal systems. It has antioxidant, antimicrobial, antiinflammatory and hepatoprotective properties. Preclinical screening of antiulcer activity of asparagus racemosus. Cox2specific inhibitors offer improved advantages over traditional nsaids. Herbal aphrodisiacs or sexual stimulant plants viz. Mulethi is useful in cough, sore throat, bronchitis, sexual weakness, skin problems, jaundice, hoarseness, vata dosha, ulcers etc. Pharmacological and therapeutic application of asparagus. In recent times, the use of herbal products has increased tremendously in the western world as well as in developed countries. The aqueous extract of glycyrrhiza glabra, emblica officinalis, zingiber officinale and asparagus racemosus were prepared using micorwave assisted extraction techniques and extracts were standardized before their use to prepare formulation. Antioxidant properties and gastroprotective effects of 2. Abstracts of papers for poster sessions indian j pharmacol. Pharmacological evaluation for antidepressantlike activity.
A series of experiments to evaluate the mechanisms of adaptogenic activity of asparagus racemosus using various stress an d immunostimulatory models are reported in the literature few of which are as sited below. Compendium of medicinal and aromatic plants volume 2. The present study aims at evaluating the selective inhibition of cox1 andor cox2 by. Andradeevaluation of antiulcer activity of the main phenolic acids. The present investigation revealed that ocimum sanctum exhibited significant antiulcer activity by enhancing antioxidant potential of gastric mucosa thereby reducing mucosal damage. To determine the effects of topical insulin administration on burn wound healing in rats with or without acute diabetes. The file contains 92 pages and is free to view, download or print. Exploring indian medicinal plants for antiulcer activity bioline. Exploring indian medicinal plants for antiulcer activity. Asparagus racemosus, asparagus adescendens, chlorophytum borivilianum, chlorophytum laxum and chlorophytum arundinaceum are regarded as source of safed musli, leading to confusion about its identity and usage, whereas asparagus species is largely employed for the treatment of female. The aqueous extract of roots increased the weight of mammary glands in post partum and estrogenprimed rats and the uterine weight in the estrogenprimed group 11. The asparagus genus asparagaceae has over 300 species which are widely distributed in temperate and tropical regions including india, china, korea and japan.
Cyperus rotundus, onosma bracteatum, barleria prionitis, citrus maxima, tinospora cardifolia and asparagus racemosus etc are significantly utilized by the local peoples of uttarakhand. There are evidences for the aid of ros in the etiology and pathophysiology of human diseases, such as neurodegenerative disorders, viral infections, autoimmune gastrointestinal inflammation. Shatavarins containing shatavarin iv with anticancer activity from. Effect of added herb extracts on oxidative stability of ghee. A potential of some medicinal plants as an antiulcer agents ncbi. The major challenge in genotoxicity testing resides in developing methods that can reliably and sensibly detect cellular response to genotoxic insult. Ayurveda research digest complete vol1 pdf free download. The analgesic activity of the ethanolic extract and its fractions has been carried out by tailflick method and writhing test at a dosage of 300 mgkg po. Antioxidant determination by the use of stable free radical. The major challenge in genotoxicity testing resides in developing methods that can reliably and. According to a 2010 study on rats, asparagus racemosus is used as a diuretic in ayurveda. The major active constituents of asparagus racemosus are steroidal saponins shatavarins iiv that are present in the roots. Bhatnagar m, sisodiya ss, bhatnagar r 2005 antiulcer and antioxidant activity of asparagus racemosus willd and withania somnifera dunal in rats.
Cuscuta, commonly known as dodder, is a genus of family convolvolaceace. Asparagus racemosus, asparagus adescendens, chlorophytum borivilianum, chlorophytum laxum and. Acute toxicity test was carried out on 36 rats 18 males and 18 females with low. Antiulcer activity of asparagus racemosus pdf free. Antiulcer activity the potent antioxidant and antiinflamatory properties of licorice makes it the best natural medicinal aid to treat ulcers of stomach, intestine and mouth. Antisecretory and antiulcer activity efficacy of a. Those possessing significant antiulcer activity have been processed further for the evaluation of the activity. The newly prepared compounds were screened for their in vitro antioxidant activities using free radical scavenging 2,2diphenyl1picrylhydrazyl dpph and ferric reducing antioxidant power frap assays. Plant profile, phytochemistry and pharmacology of asparagus racemosus.
Gastric ulceration studies have been further carried out to study the antiulcer effect of the ethanolic extract and its. The root extract of asparagus racemosus has also been traditionally used in ayurveda to increase milk secretion during lactation. Reactive oxygen species ros and free radicals such as superoxide anion radical, hydroxyl radicals, and lipid peroxides are the injurious species known to cause many degenerative diseases. Asparagus racemosus is an herbaceous perennial plant.
Ssr tamil university volume ii doctor of philosophy. Antiulcer and antioxidant activity of asparagus racemosus willd and. Publish subscribe model in webmethods pdf download. An external file that holds a picture, illustration, etc. The present study aimed to evaluate the effect of 50% ethanolic extract of asparagus racemosus whole plant extract are on phenylbutazone induced. Ssr tamil university volume ii doctor of philosophy tamil. The demand for asparagus racemosus in 20012002 was 10,924. Toxicological survey of african medicinal plants various guidelines have been established to identify potential risk for carcinogenicity and heritable mutations 56,57. There are many reasons for undertaking detailed research on the activity of. Gastroduodenal ulcer protective activity of asparagus racemosus.
Ethnoveterinary plant remedies used by nu people in nw yunnan of china. This research aims to evaluate the antiulcer properties of medicinal plants. Cistus laurifolius rockrose flowers and flower buds of cistus laurifolius l. The information provided by this web site is available in various formats, such as portable document format pdf, word, and also in html format. Metabolite profiling in biomarker discovery, enzyme substrate assignment, drug activity specificity determination, and basic metabolic research requires new data preprocessing approaches to correlate specific metabolites to their biological origin. Request pdf antisecretory and antiulcer activity of asparagus racemosus willd. They have been used as a traditional medicine for the treatment of stomach ulcers, gastritis, wounds and psoriasis. Polyherbal antiulcer formulation is developed and evaluated for various physical, chemical and biological aspects.
Asparagus rhamnose and 1 molecule of glucose figure 1. Antisecretory and antiulcer activity of asparagus racemosus willd. Preliminary report journal of scientific research in plants and medicine. A series of new 2ethylthiobenzohydrazone derivatives 16 were prepared and characterised by ir, 1h nmr, and c nmr spectroscopy and mass spectrometry. To the best of our knowledge, nothing has been reported so far on the selective inhibition of the cyclooxygenase by flavanones.
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